Tsutomu Wada Selected Research

polysaccharide-K

1/2017	Correlation Between NKG2DL Expression and Antitumor Effect of Protein-bound Polysaccharide-K in Tumor-bearing Mouse Models.
12/2013	Protein-bound polysaccharide-K augments the anticancer effect of fluoropyrimidine derivatives possibly by lowering dihydropyrimidine dehydrogenase expression in gastrointestinal cancers.
7/2013	Protein-bound polysaccharide-K induces apoptosis via mitochondria and p38 mitogen-activated protein kinase-dependent pathways in HL-60 promyelomonocytic leukemia cells.
7/2012	Protein-bound polysaccharide-K (PSK) induces apoptosis via p38 mitogen-activated protein kinase pathway in promyelomonocytic leukemia HL-60 cells.
3/2012	Polysaccharide-K (PSK) may suppress surgical stress-induced metastasis in rat colon cancer.
9/2011	Protein-bound polysaccharide-K (PSK) induces apoptosis and inhibits proliferation of promyelomonocytic leukemia HL-60 cells.
4/2011	Anti-protein-bound polysaccharide-K monoclonal antibody binds the active structure and neutralizes direct antitumor action of the compound.

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Tsutomu Wada Research Topics

Disease

28	Insulin Resistance 01/2022 - 08/2002
14	Obesity 11/2021 - 12/2006
12	Inflammation (Inflammations) 01/2022 - 01/2009
11	Type 2 Diabetes Mellitus (MODY) 11/2016 - 11/2003
8	Neoplasms (Cancer) 01/2017 - 10/2003
7	Glucose Intolerance 01/2021 - 05/2013
7	Body Weight (Weight, Body) 01/2019 - 04/2009
4	Alzheimer Disease (Alzheimer's Disease) 05/2019 - 10/2010
3	Non-alcoholic Fatty Liver Disease 01/2019 - 05/2010
3	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 12/2013 - 09/2011
3	Leukemia 07/2013 - 09/2011
3	Hypertension (High Blood Pressure) 02/2013 - 07/2007
2	Vascular Remodeling 11/2020 - 01/2017
2	Sleep Initiation and Maintenance Disorders (Insomnia) 08/2019 - 01/2018
2	Nervous System Diseases (Neurological Disorders) 05/2019 - 01/2018
2	Abdominal Obesity 10/2015 - 04/2009
2	Dyslipidemias (Dyslipidemia) 12/2013 - 05/2010
2	Colonic Neoplasms (Colon Cancer) 12/2013 - 03/2012
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 12/2013 - 05/2010
2	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 07/2012 - 09/2011
1	Spontaneous Abortion (Miscarriage) 07/2021
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 07/2021
1	Gestational Diabetes (Gestational Diabetes Mellitus) 01/2021
1	Hypertrophy 01/2019
1	Narcolepsy 01/2018
1	Tricuspid Valve Insufficiency (Insufficiency, Tricuspid Valve) 01/2018
1	Adrenocortical Carcinoma 01/2017
1	Circulating Neoplastic Cells 01/2017
1	Hyperglycemia 01/2016
1	Cognitive Dysfunction 04/2014
1	Fibrosarcoma 01/2014
1	Stomach Neoplasms (Stomach Cancer) 12/2013

Drug/Important Bio-Agent (IBA)

18	Insulin (Novolin)FDA Link 01/2022 - 08/2002
14	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 12/2006
10	Proteins (Proteins, Gene)FDA Link 11/2021 - 04/2011
8	OrexinsIBA 08/2019 - 01/2012
7	polysaccharide-KIBA 01/2017 - 04/2011
5	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2022 - 05/2005
5	LipidsIBA 01/2022 - 05/2005
5	AntioxidantsIBA 01/2022 - 07/2007
5	CytokinesIBA 01/2021 - 10/2003
4	Estrogens (Estrogen)FDA Link 01/2020 - 08/2012
4	Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA 01/2019 - 05/2010
3	Messenger RNA (mRNA)IBA 11/2021 - 12/2013
3	Eplerenone (Inspra)FDA LinkGeneric 01/2019 - 12/2013
3	streptococcal polysaccharide type III group BIBA 07/2012 - 04/2011
3	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 04/2010 - 08/2002
2	Pharmaceutical PreparationsIBA 01/2022 - 04/2013
2	Proto-Oncogene Proteins c-sis (Platelet Derived Growth Factor B)IBA 11/2020 - 01/2020
2	Platelet-Derived Growth FactorIBA 01/2020 - 01/2017
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2020 - 05/2012
2	astaxanthine (astaxanthin)IBA 01/2020 - 08/2013
2	Orexin Receptor AntagonistsIBA 08/2019 - 01/2018
2	Tamoxifen FDA LinkGeneric 01/2019 - 01/2017
2	suvorexantIBA 01/2018 - 11/2016
2	Triglycerides (Triacylglycerol)IBA 11/2016 - 05/2010
2	Nicotine FDA Link 01/2016 - 02/2007
2	Antineoplastic Agents (Antineoplastics)IBA 01/2014 - 11/2010
2	FructoseIBA 12/2013 - 05/2010
2	Nonesterified Fatty Acids (NEFA)IBA 08/2013 - 05/2010
2	p38 Mitogen-Activated Protein KinasesIBA 07/2013 - 07/2012
2	LigandsIBA 04/2013 - 05/2012
2	coenzyme Q10 (CoQ10)IBA 02/2013 - 07/2007
2	Indicators and Reagents (Reagents)IBA 02/2013 - 07/2007
2	Protein Isoforms (Isoforms)IBA 06/2011 - 01/2009
1	Inositol Polyphosphate 5-PhosphatasesIBA 01/2022
1	ebselenIBA 01/2022
1	Metformin (Glucophage)FDA LinkGeneric 01/2022
1	Chemokine CXCL12IBA 11/2020
1	ChemokinesIBA 01/2020
1	Phosphotransferases (Kinase)IBA 01/2020
1	Streptozocin (Streptozotocin)FDA Link 08/2019
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 05/2019
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 01/2019
1	InflammasomesIBA 12/2017
1	Long-Acting Insulin (Insulin, Long Acting)FDA Link 07/2017
1	Anesthetics (Anesthetic Agents)IBA 01/2017
1	Platelet-Derived Growth Factor beta Receptor (Receptor, Platelet Derived Growth Factor beta)IBA 01/2017
1	Glucagon (Glukagon)FDA Link 11/2016
1	Drinking WaterIBA 01/2016
1	Cholinergic Agents (Cholinergics)IBA 01/2016
1	Therapeutic UsesIBA 10/2015
1	Dipeptidyl-Peptidase IV InhibitorsIBA 10/2015
1	3- (4- (4- (3- methyl- 1- phenyl- 1H- pyrazol- 5- yl)piperazin- 1- yl)pyrrolidin- 2- ylcarbonyl)thiazolidineIBA 10/2015
1	2,4-thiazolidinedione (thiazolidinedione)IBA 04/2014
1	Glucagon-Like Peptide-1 ReceptorIBA 04/2014
1	MethylcholanthreneIBA 01/2014
1	doxifluridineIBA 12/2013
1	Sterol Regulatory Element Binding Protein 1IBA 12/2013
1	EnzymesIBA 12/2013
1	Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)IBA 12/2013
1	Fluorouracil (Carac)FDA LinkGeneric 12/2013
1	Thymidine PhosphorylaseIBA 12/2013
1	Thymidylate SynthaseIBA 12/2013
1	TransferasesIBA 12/2013

Therapy/Procedure

6	Therapeutics 07/2021 - 09/2011
3	Tissue Expansion 11/2020 - 01/2019
1	Injections 07/2021
1	Catheters 01/2018
1	Chronotherapy 01/2016